KEMV992: CH2: Determination of Solution Phase Structures

by Elina Kaarina Leskinen last modified Aug 07, 2012 03:23 PM
Although solid-state structures, determined mainly by crystallographic methods, continue to be one of the major methods for the determination of three-dimensional structures of molecules and complexes, in many cases these methods are not applicable due to the lack of suitable crystals. In these cases, the best alternatives involve the determination of solution phase structures by a combination of NMR methods and molecular modeling. The aim of this course is to introduce the students to the basics of both methods and especially how their combination can be used as a highly powerful tool for assigning and determining the structures and conformations of small molecules and their complexes.